ATTD: Advanced Technologies and Treatments for Diabetes

The Science Behind Weekly Insulin

September 22, 2026·21 min
Episode Description from the Publisher

In this episode, we explore the science behind weekly insulin, including the pharmacology of weekly insulin, its mechanism of action, how it differs from daily insulin formulations, and why it provides consistent control over a longer period.Guest: Dr. Manasi Shah, Assistant Professor of Medicine at Eastern Virginia Medical School and Director of the Inpatient Diabetes Program at Sentara Norfolk General HospitalKey discussion points:What are the key pharmacokinetic properties that enable once-weekly insulin administration?How does the pharmacodynamic profile differ from that of daily basal insulin formulations?What mechanisms allow weekly insulin to provide sustained glucose control over several days?How does this prolonged action translate into clinical glycemic stability?What are the key pharmacological considerations clinicians should be aware of when interpreting data on weekly insulin?What remaining scientific questions need to be addressed before broader clinical adoption?You can find more resources on the ATTD Education Portal. Register now to access exclusive content and stay ahead in the field.This series is supported by Eli Lilly & Company

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