Digital Pathology Podcast

249: Cytopathology AI: Crowded-Cell Gaps and LLM Guardrails

August 31, 2026·30 min
Episode Description from the Publisher

Send us Fan Mail What happens when AI models that perform almost perfectly on scattered cervical cells become less reliable than a coin flip on crowded cell groups? In DigiPath Digest #51, I examine what this performance gap tells us about artificial intelligence in cytopathology. The first paper evaluated six convolutional neural network models trained to distinguish benign from high-grade lesions using scattered cervical cytology cells. The models achieved AUCs ranging from 0.950 to 0.996 o...

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