#162 - Meet The Scientist Who Says We've Gotten Cancer Completely Wrong

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing 👇https://www.youtube.com/@thegiantsshoulder/joinCarlos Sonnenschein is Professor of Integrative Physiology and Pathobiology at Tufts University School of Medicine. With Ana Soto, he developed the tissue organisation field theory of cancer: the idea that a tumour begins not in a rogue cell, but in the breakdown of the tissue around it. For fifty years he has argued that cancer research has been looking one level too low. Here he explains why the mutations we find in tumours may be the wreckage, not the cause.Expect to learn:- The default state: why every cell's natural tendency is to proliferate- Growth factors: why he argued they don't exist, and why people laughed- Mutations without cancer: why he says no gene has been shown to cause a cancer- Targeted therapy: why he believes the target was never really there- Cellular agency: how life, proliferation and motility fit togetherSPONSORSGet Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderGS EPISODES MENTIONEDMichael Levin - Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://youtu.be/LTBZRVKUwyMGUEST LINKSGoogle Scholar: https://scholar.google.com/citations?user=VmTCfroAAAAJIEA Nantes Fellow Profile: https://www.iea-nantes.fr/en/fellows/carlos-sonnenscheinBiological Purpose Project: https://www.biologicalpurpose.org/people/carlos-sonnenscheinResearchGate: https://www.researchgate.net/profile/Carlos-SonnenscheinAn Integrative Approach Toward Biology, Organisms, and Cancer (2018): https://pubmed.ncbi.nlm.nih.gov/29119499LISTEN ONYouTube - https://youtu.be/AypMhvhWwjgApple - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249SKOOLWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:26 From Paediatrics to Cancer Research0:05:23 The Oestrogen Paradox0:08:43 Proliferation Is the Default State of Every Cell0:12:27 Inhibitors of Inhibitors0:14:06 "Growth Factors Don't Exist"0:15:31 The Somatic Mutation Theory0:17:41 The Society of Cells and the Tissue Theory of Cancer0:21:44 Stars and Dogs: Funding a Minority View0:23:49 Teaching Cancer Through Genetics0:25:01 How Does Tissue Keep Cells in Check?0:26:04 Metastasis0:28:34 Prostate Cancer and Spontaneous Regression0:30:38 The Cost of Cancer Treatment0:31:49 Melanoma, UV and the Standard Model0:32:24 Mutations Without Cancer0:35:17 No Gene Causes Cancer: BRCA1, p53 and RAS0:37:00 Why Targeted Therapy Isn't Targeted0:38:03 When Treatment Causes Cancer0:40:39 What Does Genome Sequencing Tell You?0:42:24 Why Does Cancer Run in Families?0:45:41 Trauma, Healing and Tissue Robustness0:47:59 A Theory of Organisms0:50:59 What Is Life?0:52:18 Economics Is a Branch of Biology0:53:36 Cellular Agency0:58:36 Defining Life: Proliferation and Motility1:01:36 When Did Cells Become Agents?1:04:49 The Future of Cancer Research1:09:52 Final Thoughts.....Email for sponsorship enquiries: evan@thegiantsshoulder.com