Gladden Longevity Podcast

How Bitter Taste Receptors in Your Gut Can Instantly Kill Food Cravings - Episode 339

May 7, 2026·28 min
Episode Description from the Publisher

In this episode, Dr. Gladden and nutrition expert Sarah Kennedy discuss Calocurb, a natural extract that uses evolutionary biology to suppress appetite. The discovery focuses on bitter taste receptors (T2Rs) located throughout the gastrointestinal tract, which historically served as a protective mechanism to slow the consumption of potentially toxic substances. By using a specific New Zealand hop extract, Calocurb triggers these receptors to signal the brain that the body is full. This process stimulates the natural release of satiety hormones—GLP-1, CCK, and PYY—effectively quieting "hunger noise" and reducing caloric intake without the need for synthetic pharmaceuticals.   For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now   Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!    Takeaways ·       Sarah Kennedy transitioned from veterinary medicine to nutrition. ·       Calocurb is based on the hypothesis of appetite suppression through bitter taste receptors. ·       Bitter taste receptors are present throughout the gastrointestinal tract. ·       The primary hormones involved in appetite suppression are CCK, GLP-1, and PYY. ·       Clinical studies showed an 18% reduction in calorie intake with Calocurb. <span style="mso-l

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