
This week, we feature new research on transcatheter treatment for tricuspid regurgitation, multicancer early-detection testing, resuscitation strategies for septic shock, and an experimental approach to restoring vision. We review advances in breast cancer treatment, follow a puzzling case of prolonged fever and lymphadenopathy, and report on scientific reproducibility. Perspectives discuss outbreak response, obesity trials, and the enduring value of the medical generalist. Supplement to the New England Journal of Medicine, Vol. 395, No. 14.
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