NYU Langone Insights on Psychiatry

Interventional Approaches to Treatment-Resistant Mood Disorders

December 26, 2025·19 min
Episode Description from the Publisher

Joshua Berman, MD, PhD, discusses how careful evaluation, patient priorities, and risk-benefit tradeoffs guide the use of interventional treatments when conventional approaches fall short. Dr. Berman also explains how tools such as ketamine, TMS, ECT, and neurofeedback can be used strategically—sometimes in sequence or combination—to address different vulnerabilities within mood-related brain circuits. Dr. Berman is Associate Professor of Psychiatry and Director of Interventional Psychiatry a...

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