The Giants Shoulder

#122 - Meet the Psychiatrist Training To Be An Ayahuasca Shaman

May 21, 2026·1h 39m
Episode Description from the Publisher

Want to truly understand your own conscious inner experience? I built a tool and its free - https://www.skool.com/the-giants-shoulder-6526/aboutDr Simon Ruffell is a clinical psychiatrist and the CEO of Onaya Science, the research organisation that studies Amazonian ayahuasca healing alongside Shipibo curanderos in the Peruvian rainforest. His team ran the first-ever study on a psychedelic and human epigenetics — finding that ayahuasca methylates the trauma-memory gene SIGMAR1, mapping precisely onto what the Shipibo have called "cleaning ancestral lines" for thousands of years.Expect to learn why a Maudsley-trained psychiatrist walked away from the NHS to apprentice as a Shipibo shaman, what happens when a curandero performs an exorcism on you mid-ceremony, how 80% of veterans no longer met PTSD criteria six months after a two-week retreat, why the curandero traditionally drinks the ayahuasca and the patient doesn't, what happened when Simon gave a Shipibo curandero a hit of pure crystal DMT, why DMT entities might be real and where Robin Carhart-Harris and Andrew Gallimore disagree about it, and much more…Timestamps:00:00 Trailer03:20 What is Shipibo Curanderismo?04:52 From disillusioned NHS psychiatrist to the Peruvian Amazon10:14 First ayahuasca: shown two versions of myself15:41 The demon attack and the three suckers26:13 Bridging Western psychiatry and Amazonian shamanism36:04 Are DMT entities real? Carhart-Harris vs Gallimore49:50 Inside the multimodal veteran PTSD study52:41 DMT vs ayahuasca — what's actually different57:11 Should you try this? Preparation and "gringo wasca"1:04:52 The first-ever psychedelic epigenetics study (SIGMAR1)1:12:17 "Cleaning ancestral lines" — when Indigenous science met Western1:16:51 80% no longer meet PTSD criteria — the real numbers1:20:37 The shaman drinks, not the patient — traditional protocol1:30:41 The spiritual mechanism of action1:34:54 The dream experiment — plant personalitiesEmail for sponsorship enquiries: evan@thegiantsshoulder.com FOLLOW SIMON:Website: https://www.drsimonruffell.comInstagram: @sgdruffellOnaya Science: https://www.onaya.ioHeroic Hearts UK: https://www.heroicheartsuk.orgPAST EPISODES MENTIONED:Robin Carhart-Harris — Entropic Brain, How Psychedelics Really Work and Consciousness: https://youtu.be/t-GkE4YtLRkAndrew Gallimore — DMT Neurobiologist: Alien Worlds, Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDAGrace Blest-Hopley — Psychedelics Expert: Who is Blocking Psychedelic Research?: https://www.youtube.com/watch?v=FBcLxMfUzxw

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