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Concentrating on Chromatography: Daily Summaries Delivered
by David Oliva
Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!
Latest Episodes
The most recent episodes — sign up to get AI-powered summaries of each one.
- 4 days ago40 min
Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
In this episode of @ChromatographyTalk , David speaks with Joseph Corstvet from the Fernandez Lab at Georgia Tech about the future of mass spectrometry, LC-MS metabolomics, and the development of low-cost ionization technologies.Joe discusses his work using LC-MS lipidomics to monitor mesenchymal stromal cell (MSC) senescence and explains how metabolomics could eventually become a real-world quality control tool for regenerative medicine and cell therapy manufacturing.The conversation also dives into triboelectric nanogenerators (TENGs) and how these low-cost, modular ionization systems could help make mass spectrometry more portable, accessible, and affordable. Joe explains how TENG-powered electrospray ionization works, why it differs from traditional ESI, and how his group is exploring applications ranging from mass spectrometry imaging to mobile MS platforms.Topics include:• LC-MS metabolomics workflows• Lipidomics and MSC senescence• Biomarker discovery in regenerative medicine• Untargeted metabolomics challenges• TENG ionization technology• Portable and lower-cost mass spectrometry• Mass spectrometry imaging• Ion mobility and future MS trends• ASMS and the future of analytical chemistryIf you enjoy conversations about chromatography, mass spectrometry, metabolomics, and analytical chemistry innovation, be sure to subscribe to Concentrating on Chromatography.#MassSpectrometry #LCMS #Metabolomics #AnalyticalChemistry #Chromatography #Lipidomics #MassSpec #Ionization #ASMS #Biotech
- 1 weeks ago48 min
Episode 62: When One Atom Changes Everything | JC Poutsma on Mass Spectrometry, Proteomics & Gas-Phase Chemistry
What happens when you replace just one atom in an amino acid?In this episode of @ChromatographyTalk David sits down with JC Poutsma, Professor of Chemistry at William & Mary, to explore the fascinating world of gas-phase ion chemistry, peptide fragmentation, and the hidden molecular behavior revealed by mass spectrometry.Professor Poutsma explains how subtle structural changes in biomolecules can dramatically alter protein folding, fragmentation pathways, and biological activity. The conversation dives into unusual amino acids like canavanine, the “proline effect” in peptide fragmentation, ion mobility spectrometry, IR spectroscopy, and why understanding the fundamentals of chemistry still matters in modern analytical science.Whether you work in LC-MS, proteomics, physical chemistry, or analytical instrumentation—or you simply enjoy learning how molecules behave at the most fundamental level—this episode offers a fascinating look at the chemistry happening behind the spectra.Topics Discussed* What is gas-phase ion chemistry?* How mass spectrometers can function as reaction vessels* Why unusual amino acids matter* The chemistry of canavanine vs arginine* How one atom substitution changes protein behavior* Peptide fragmentation mechanisms in proteomics* The “proline effect” in tandem MS* Ion mobility spectrometry explained* IR spectroscopy for structural characterization* Why understanding analytical fundamentals still matters* Teaching chemistry in the age of AI and automation About the GuestJC Poutsma is a Professor of Chemistry at William & Mary whose research focuses on gas-phase ion chemistry, biomolecular structure, peptide fragmentation, spectroscopy, and the physical chemistry underlying mass spectrometry.#MassSpectrometry #Proteomics #AnalyticalChemistry #LCMS #MassSpec #Chemistry #IonMobility #Spectroscopy #PeptideFragmentation #PhysicalChemistry #ASMS #Chromatography
- 2 weeks ago38 min
Episode 61: Why Biologics QC Is So Much Harder Than Small Molecule Pharma | Colette Quinn of Waters
In this episode of @ChromatographyTalk David speaks with Colette Quinn, Senior Director within the Biologics Business at Waters Corporation, about the rapidly evolving world of pharmaceutical and biopharma QA/QC.As biologics become more complex, QA/QC labs are being pushed beyond traditional pass/fail testing toward deeper molecular characterization, advanced analytics, and data-driven decision making. Colette explains why “the product is the process” in biologics manufacturing, how chromatography and mass spectrometry are transforming QC workflows, and why orthogonal analytical techniques are becoming increasingly important for understanding critical quality attributes (CQAs).The conversation explores:* Why biologics QC differs fundamentally from small molecule pharma* The growing role of LC, HRMS, MALS, CE, and 2D-LC in QA/QC* Challenges surrounding aggregation, co-elution, heterogeneity, and higher-order structure* How automation, software, and machine learning may reshape future QC labs* The importance of data integrity and standardized workflows* Why advanced techniques like MALS and mass spectrometry are moving downstream into QC environments* How QC teams can think scientifically about adopting new analytical technologiesColette also shares insights on building high-performing analytical teams, the skills needed by the next generation of QC scientists, and where she believes the future of real-time release testing and biologics characterization is headed.Whether you work in chromatography, mass spectrometry, pharmaceutical analysis, biologics development, or analytical chemistry, this episode offers a detailed look at how modern QA/QC is evolving alongside increasingly sophisticated therapeutics.#Chromatography #MassSpec #Biologics #Pharma #Biopharma #QualityControl #QAQC #LCMS #MALS #AnalyticalChemistry #Waters #PharmaceuticalAnalysis #Biotechnology #2DLC #QC #MassSpectrometry
- 3 weeks ago16 min
Episode 60: Why Capillary LC Is the Future of LC-MS Sensitivity #chromatography #massspectrometry
What makes capillary LC so powerful—and why are more scientists paying attention to it?In this episode of @ChromatographyTalk , David sits down with Samuel Foster of Axcend to discuss how capillary liquid chromatography is changing the conversation around LC-MS sensitivity, solvent consumption, instrument footprint, and chromatographic efficiency.Sam explains how lower flow rates can dramatically improve electrospray ionization performance, why capillary LC can reduce solvent usage by orders of magnitude, and where the technology is already making an impact in pharmaceutical, environmental, and radiopharmaceutical workflows.They also discuss common misconceptions about capillary LC, why older systems gave the technology a mixed reputation, and why modern advances may make now the right time for labs to take another look.Topics Covered:* What capillary LC is and how it differs from traditional HPLC* Why lower flow rates improve LC-MS sensitivity* Solvent savings and sustainability benefits* Extra-column effects and hidden performance killers* Applications in pharma, biologics, drugs of abuse, and radiopharmaceuticals* Is capillary LC ready for routine lab adoption?* The future of liquid chromatographyIf you work in LC, LC-MS, analytical chemistry, method development, or lab operations, this episode is packed with practical insight.👍 Like, comment, and subscribe for more conversations with leaders in analytical science.#Chromatography #HPLC #LCMS #MassSpectrometry #AnalyticalChemistry #PharmaceuticalAnalysis #LabScience #CapillaryLC
- May 4, 202630 min
Episode 59: The Future of Ion Chromatography | PFAS Testing, EPA 1621 & AOF Explained #analyticalchemistry
How are PFAS regulations changing, and what role will ion chromatography play in the future of environmental testing?In this episode of @ChromatographyTalk , David interviews Jay Gandhi, PhD, Vertical Markets Manager at Metrohm USA, for an in-depth discussion on PFAS analysis, the rise of AOF (Adsorbable Organic Fluorine) testing, and the development of EPA 1621 and ISO 18127 standards.With more than 30 years of experience in ion chromatography, Jay shares valuable perspective on how the field has evolved—from early applications and NASA water recovery projects to today’s challenges involving PFAS, TFA, and emerging contaminants.Topics covered in this episode include:• What PFAS are and why they matter• The difference between targeted PFAS methods and AOF analysis• How combustion ion chromatography works• Behind the scenes of EPA 1621 and ISO 18127 method development• Regulatory trends in water, textiles, and food packaging• TFA analysis using IC-MS and IC-MS/MS• The future of ion chromatography in environmental labsWhether you work in analytical chemistry, environmental testing, water analysis, or chromatography, this episode offers timely insights from one of the industry’s leading experts.Subscribe for more interviews with scientists, researchers, and industry leaders.#PFAS #Chromatography #IonChromatography #EnvironmentalTesting #Metrohm #AnalyticalChemistry #MassSpectrometry #EPA
- Apr 27, 202623 min
Episode 58: How Separation Science Is Taught vs. How It’s Actually Used #nmrspectroscopy #massspectrometry
What do students really learn before they ever touch an analytical instrument? And is chemistry education keeping up with the pace of modern chromatography, mass spectrometry, and sample preparation?In this episode of Concentrating on Chromatography, David speaks with instructor Natasha Le about the realities of teaching chemistry and separation science to today’s students—many of whom are pursuing careers in medicine, pharmacy, dentistry, and healthcare rather than research.Natasha shares what students struggle with most, why many learners become focused on grades instead of understanding the science, and where the gap exists between textbook chemistry and real-world lab workflows.Topics include:🔹 When students first encounter separation science concepts🔹 Why chromatography is often taught without being labeled as such🔹 The challenge of teaching critical thinking vs. “button pushing”🔹 How mass spectrometry differs in the classroom vs. real labs🔹 Why sample prep skills matter more than students realize🔹 Can universities keep up with rapidly changing analytical technology?🔹 What separates a good chemistry student from a great oneIf you work in chromatography, mass spectrometry, lab education, or are preparing for a career in analytical chemistry, this conversation offers a valuable look at how the next generation is being trained.#Chromatography #MassSpectrometry #AnalyticalChemistry #STEMEducation #HPLC #GCMS #LCMS #ChemistryStudents #SamplePrep #Podcast
- Apr 20, 202646 min
Episode 57: Frugal Science Meets Sample Prep: A Field-Ready Lyophilizer for Biofluids
What if you could dry biofluid samples in the field—without a vacuum system, freeze dryer, or full lab setup?In this episode of Concentrating on Chromatography, I sit down with Rajas Poorna and Charles Anderson to explore their work on a frugal, field-deployable alternative to traditional lyophilization through the Evapinator project.Originally inspired by the principles of frugal science, their approach rethinks how we stabilize and prepare biofluid samples like blood and plasma—especially in environments where traditional lab infrastructure simply isn’t available.--- 🔬 What This Episode Covers: 🧪 A Frugal Take on Lyophilization* Can you replicate the outcome of a lyophilizer without the complexity?* Why traditional freeze drying is often too expensive and impractical for field use* How simplifying evaporation could unlock entirely new workflows 🌍 Drying Biofluids in the Field* The real-world challenge of handling blood and other biofluids outside the lab* Why sample stability during transport is such a critical bottleneck* How a portable system could enable on-site sample prep in remote or resource-limited settings ⚗️ Rethinking Evaporation (No Vacuum Required)* The core idea behind the Evapinator—and how it challenges conventional assumptions* The role of airflow, heat, and design in drying sensitive samples* Where this approach fits relative to traditional evaporation and lyophilization techniques 🛠️ Early Results & Practical Insights* What’s working so far—and where limitations still exist* The types of applications where this approach shows the most promise* What still needs to be validated in upcoming peer-reviewed work--- ⚗️ Why This MattersFrom clinical research in remote regions to decentralized diagnostics, the ability to dry and preserve biofluid samples in the field could fundamentally change how and where analysis happens.This conversation challenges a core assumption in analytical science:Do you really need a full lyophilizer—or even a vacuum—to stabilize biofluid samples?--- 🚀 What’s NextThis is Part 1 of the conversation.In the follow-up episode, we’ll dive into the peer-reviewed data, performance validation, and how this approach compares directly to traditional lyophilization and evaporation systems.---## 🎧 About the Show @ChromatographyTalk explores the people, technologies, and ideas shaping analytical science—from the lab bench to the field.
- Apr 13, 202621 min
Episode 56: Fighting Antibiotic Resistance with LC-MS: Targeting Bacterial Cell Walls #chromatography #massspec
In this episode of Concentrating on Chromatography, host Dave Oliva sits down with Chris Reid to explore how chemical biology and LC-MS are being used to tackle one of the most urgent global challenges: antimicrobial resistance.As antibiotic resistance continues to rise—and new drug development struggles to keep pace—researchers are looking beyond traditional approaches. Instead of targeting how bacteria build their cell walls, Chris’s work focuses on how they break them down, opening the door to entirely new antimicrobial strategies.--- 🔬 What You’ll Learn in This Episode:* Why antimicrobial resistance is accelerating globally* What peptidoglycan is and why it’s essential to bacterial survival* How targeting cell wall degradation differs from traditional antibiotics* The strategy behind designing small molecule probes and inhibitors* How LC-MS is used to analyze peptidoglycan fragments and enzyme activity* Key analytical challenges: complex mixtures, low-abundance species, and structural similarity* The importance of sample preparation and reproducibility in LC-MS workflows* How this research could lead to new antibiotic targets--- ⚗️ LC-MS in FocusThis episode dives deep into how LC-MS enables:* Detection of peptidoglycan fragment profiles* Analysis of cross-linking patterns via retention time and mass* Identification of structural changes using tandem mass spectrometryChris also shares practical insights on:* Sample prep challenges with insoluble biomaterials* Common pitfalls in LC-MS workflows* How to ensure consistent, reproducible data--- 🚀 Why This MattersWith bacteria rapidly evolving resistance to existing drugs, the need for new antimicrobial strategies has never been greater. This research highlights how combining chemistry, biology, and analytical science can uncover entirely new ways to fight infection.--- 🎧 About the Show @ChromatographyTalk explores the intersection of analytical chemistry, sample preparation, and real-world applications across research and industry.--- 🔔 Subscribe for more conversations on:* LC-MS & chromatography* Sample preparation strategies* Real-world analytical workflows* Emerging applications in life sciences--- 🧠 Key Takeaway “We’re rapidly running out of tools in our arsenal to combat resistant organisms.”
About Concentrating on Chromatography
Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!
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