The Active Site

The Truth About Brain Magnesium

May 26, 2026·12 min
Episode Description from the Publisher

For decades, magnesium sat in the supplement aisle as a mineral for muscle cramps, sleep, and general nutrition. Around 2010, that changed. A branded form called magnesium L-threonate launched on the back of a 2010 MIT rodent paper, and a new category was born — magnesium for the brain. Fifteen years later, that category has expanded to include other brand-targeted forms, premium price points, and confident claims about cognition, memory, and synaptic density. In this investigation, we review...

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