Why Do My Mast Cells React to Stress? Dr. Bruce Hoffman

 Full show notes + resources[COMPANION GUIDE NAME]: Every term from this conversation explained in plain words, in the order it comes up.First it was one food. Now it is smells, supplements, heat and stress, and the list keeps growing.What will surprise you is that mast cells respond to your total load, and a sensitized system can react to the thought of a trigger alone.This is Part 1 of a two-part conversation. [Part 2 is here: EP 198 LINK]Dr. Aimie sits down with Dr. Bruce Hoffman, who spent 30 years treating highly reactive, complex chronically ill patients. He explains why stress, from early trauma or daily life, is the largest trigger of mast cell activation he sees, and why the trigger list grows as toxins, processed food and indoor living add to the load.Dr. Aimie breaks down the cell danger response, the footprint childhood trauma leaves as oxidative damage, and the two-way loop that keeps mast cells and the nervous system setting each other off.WHAT YOU'LL LEARN:00:00 Why are so many people reacting to everything?02:52 How does early childhood trauma load the mast cells?05:39 What is the cell danger response?09:16 Why does childhood trauma show up as oxidative damage today?12:32 Why does the trigger list keep getting longer?14:39 What sets the threshold for mast cell activation?17:58 Can mast cells react to a threat that is only predicted?22:19 How do mast cells keep the nervous system on alert?24:10 Why do people react to the supplements meant to help them?27:21 Why does a roadmap create safety?"You don't even have to have the threat. You can just think about it and your mast cells degranulate." — Dr. Bruce HoffmanIf you react to more foods, smells and supplements every year and no one can tell you why, this episode is for you.RESOURCES:Get the free [COMPANION GUIDE NAME]. Every term from this conversation explained in plain words, in the order it comes upGet The Biology of Trauma book. Chapter 4 covers the cell danger responseNever Bet Against Occam by Dr. Lawrence Afrin   Grab your copy of The Biology of Trauma