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by Y Combinator
We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
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Sam Altman reflects on the evolution of startups from the early Y Combinator days to the AI-driven era, arguing that now is the best time in history to start a company. With AI drastically reducing development time and enabling unprecedented ambition, he urges founders to pursue bold, contrarian ideas despite skepticism, emphasizing that distributed power through startups is key to ensuring AI benefits society.
Fresh off the launch of Opus 5, Claude Code creator Boris Cherny joins Diana Hu at Startup School 2026 to talk about what the newest models can do, how Claude Code came to be, and what it means to build products when the underlying capabilities keep accelerating.
NVIDIA started with the wrong technology, learned the right one from three textbooks bought at Fry’s, and went on to invent most of the major breakthroughs in modern computing.At Startup School 2026 at Chase Center, Garry Tan sits down with Founder and CEO Jensen Huang to talk about confronting reality, learning your way into new domains, and why resilience — getting through one day at a time — matters more than anything else.
Sample efficiency remains one of the most critical challenges in AI, with humans vastly outperforming models in learning from minimal data. World models—predictive models of environment dynamics—are emerging as a leading solution, enabling agents to simulate outcomes and plan without costly real-world interactions. This episode explores the theory, math, and real-world applications of world models, arguing they may be essential for achieving AGI.
Founders often rely on aggregate metrics like DAUs or MAUs, which obscure how individual users actually engage with a product. The dot plot is a simple yet powerful visualization tool that reveals usage patterns, retention issues, and feature-level behaviors by mapping individual user activity over time. Unlike aggregate graphs that trend upward regardless of real engagement, dot plots expose whether users are consistently deriving value, making them essential for early-stage founders who need to understand not just if people use their product, but how they use it.
Ploy, founded by Webflow co-founder and CTO Bryant Chou, leverages AI to transform static websites into intelligent, self-optimizing marketing platforms that automate SEO, content creation, design, and customer acquisition — effectively acting as an AI-powered CMO, designer, and developer in one. The platform uses deep contextual understanding and curated design intelligence to avoid 'AI slop' and deliver bespoke, high-performing websites that evolve over time.
Founders should stop overthinking and instead commit fully to one startup idea, go deep on customer understanding, and validate through real-world execution. True insight emerges not from abstract analysis but from immersive, focused engagement with a problem space—especially in the AI era, where surface-level software solutions are commoditized and full-stack verticalization is required to build defensible businesses.
Pedro Franceschi, CEO of Brex, argues that AI is a foundational technological shift akin to the invention of electricity, and that founders and CEOs must become the chief AI officers of their companies, rethinking every process from first principles using agentic AI systems. The future of startups isn’t about efficiency—it’s about reimagining the very fabric of how companies are built, with AI as the core architect.
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We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
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