Huberman Lab

Essentials: The Science & Treatment of Obsessive Compulsive Disorder (OCD)

July 9, 2026·35 min·5-min readsoloscience
Podzilla Summary (5 min)
TLDR
Obsessive-compulsive disorder (OCD) is a highly prevalent and debilitating condition rooted in a specific neural circuit — the corticostriatothalamic loop — and is best treated through exposure-based cognitive behavioral therapy (CBT), which outperforms SSRIs and even their combination. W

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Guest

D

Dr. Helen Blair Simpson

solo on Huberman Lab

Mentions

Books, people, and resources mentioned in this episode.

People

Dr. Helen Blair SimpsonDr. Huberman

Companies

Eight SleepRora

Products & Tools

Yale-Brown Obsessive-Compulsive ScaleAG1

Research & Papers

Acute Effects of Cannabinoids on Symptoms of Obsessive-Compulsive Disorder, Human Laboratory Study

Topics

AnxietyBiohackingLongevityMental HealthNeuroscienceScientific MethodTherapy

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